Author: Gupta, Neha; Richter, Robert; Robert, Stephen; Kong, Michele
Title: Viral Sepsis in Children Document date: 2018_9_18
ID: 050vjj6k_35
Snippet: Prevention of neonatal HSV infection is more elusive as neonatal HSV disease often occurs after transmission from asymptomatic women with primary HSV infection (162) . In cases of active maternal genital herpes, cesarean sections can decrease the incidence of neonatal HSV infection, especially when performed within 4 h of rupture of membranes (163) . A subunit HSV vaccine has shown promising results in prevention of genital herpes and is currentl.....
Document: Prevention of neonatal HSV infection is more elusive as neonatal HSV disease often occurs after transmission from asymptomatic women with primary HSV infection (162) . In cases of active maternal genital herpes, cesarean sections can decrease the incidence of neonatal HSV infection, especially when performed within 4 h of rupture of membranes (163) . A subunit HSV vaccine has shown promising results in prevention of genital herpes and is currently under Phase III trial (164) . Although not routinely recommended, antiviral prophylaxis with acyclovir in late pregnancy has been demonstrated to decrease viral shedding, leading to reduction in cesarean rates and recurrent herpes (165, 166) . Patients with severe neonatal HSV infection (those with disseminated disease and CNS infection) should be treated with intravenous acyclovir for 21 days (167) .
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