Human core duplicon gene families: game changers or game players?

Bekpen, Cemalettin; Tautz, Diethard

A first description of the evolution of TRIM51 genes is included in a general study of TRIM genes by Han et al. [17] , who showed that TRIM51 genes are recently duplicated, hominoid-specific TRIM genes. Some of the TRIM51 genes (C1,C2) were found to have CNV in human individuals and to evolve under positive selection [17] . The human genome assembly includes seven fulllength, duplicated copies of TRIM51 (SPRYD5) genes, at least five fragmented duplication blocks that are expanded mainly within the centromeric region of chromosome 11 and an additional copy on chromosome 2 (TRIM51JP). Comparisons of the available assembled genomes (rheMac8, ponAbe3 and hg38) in the UCSC genome browser and Synteny in Ensembl indicate that TRIM51 genes initially evolved by segmental duplication from TRIM51EP. There is a single full-length copy in the macaque genome, which shows high similarity to human TRIM51EP. However, more detailed work is required to resolve this.