Immunomodulatory Effect after Irreversible Electroporation in Patients with Locally Advanced Pancreatic Cancer

He, Chaobin; Wang, Jun; Sun, Shuxin; Zhang, Yu; Li, Shengping

. . Clinical Data Collection. The following clinical and radiological data were retrieved from medical record archived at Sun Yat-sen University Cancer Center, including age, gender, tumor size, tumor grade, tumor site, white blood cell (WBC) count, platelet (PLT) count, serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT), albumin (ALB), total bilirubin (TBIL), indirect bilirubin (IBIL), Creactive protein (CRP), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9). The inflammationbased indexes, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic index (PI), and modified Glasgow Prognostic Score (mGPS), were also entered into this study. The thresholds for the clinical or radiological variables were used as the cutoff values. With the cutoff value of 1.47 and 165.29, NLR and PLR were associated with the optimal Youden indexes for OS and progression-free survival (PFS) prediction, respectively. The defined score of other inflammation-based indexes, such as PI and mGPS, had been described in previous studies [19] .