Author: Elste, James; Kaltenbach, Dominik; Patel, Vraj R.; Nguyen, Max T.; Sharthiya, Harsh; Tandon, Ritesh; Mehta, Satish K.; Volin, Michael V.; Fornaro, Michele; Tiwari, Vaibhav; Desai, Umesh R.
Title: Inhibition of Human Cytomegalovirus Entry into Host Cells through A Pleiotropic Small Molecule Document date: 2020_2_29
ID: 031ro01b_19
Snippet: A priori, an anti-viral inhibition strategy revolving on competitive antagonism to host cell entry does not have to rely on any changes on gene expression, either for the virus or for the host. However, evidence of gene expression changes, especially of those involved in viral entry, propagation and spread, may help better understand an agent's mechanism of action. Thus, we focused on whether the expression of immediate early (IE) genes of HCMV a.....
Document: A priori, an anti-viral inhibition strategy revolving on competitive antagonism to host cell entry does not have to rely on any changes on gene expression, either for the virus or for the host. However, evidence of gene expression changes, especially of those involved in viral entry, propagation and spread, may help better understand an agent's mechanism of action. Thus, we focused on whether the expression of immediate early (IE) genes of HCMV are altered.
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