Selected article for: "anti hiv activity and HIV infection"
Author: Leclercq, Loïc
Title: Interactions between cyclodextrins and cellular components: Towards greener medical applications?
  • Document date: 2016_12_7
    • ID: 16pzlvzz_70
    Snippet: The HIV is a widely studied virus in terms of the effects of CDs. For instance, sulfated CDs are able to inhibit HIV infection [151, 152] . In 1998, Leydet et al. demonstrated anti-HIV and anticytomegalovirus activity of several charged CD derivatives [153] . In 2008, Liao et al. reported that HP-β-CD exhibits also an anti-HIV activity based on cholesterol depletion [154] . However, the mechanism had not yet been determined. Since the membrane c.....
    Document: The HIV is a widely studied virus in terms of the effects of CDs. For instance, sulfated CDs are able to inhibit HIV infection [151, 152] . In 1998, Leydet et al. demonstrated anti-HIV and anticytomegalovirus activity of several charged CD derivatives [153] . In 2008, Liao et al. reported that HP-β-CD exhibits also an anti-HIV activity based on cholesterol depletion [154] . However, the mechanism had not yet been determined. Since the membrane cholesterol [155] and lipid raft-based receptors [156] are strictly required for infectivity and HIV entry, CDs are excellent candidates for its use as a chemical barrier for AIDS prophylaxis.

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