Author: Rhein, Bethany A.; Powers, Linda S.; Rogers, Kai; Anantpadma, Manu; Singh, Brajesh K.; Sakurai, Yasuteru; Bair, Thomas; Miller-Hunt, Catherine; Sinn, Patrick; Davey, Robert A.; Monick, Martha M.; Maury, Wendy
Title: Interferon-? Inhibits Ebola Virus Infection Document date: 2015_11_12
ID: 10bu7iwg_12
Snippet: While studies above indicated that IFNγ blocked EBOV and EBOV GP/rVSV infection of macrophages from wild-type mice, EBOV GP/rVSV infection of these cells was modest and virus spread in these cultures was not observed. In contrast, macrophages from BALB/c or C57BL/6 IFNAR -/mice were highly permissive to EBOV GP/rVSV and IFNγ treatment of these cells profoundly decreased infection in a dose dependent manner (S3A and S3B Fig) . Hence, we used per.....
Document: While studies above indicated that IFNγ blocked EBOV and EBOV GP/rVSV infection of macrophages from wild-type mice, EBOV GP/rVSV infection of these cells was modest and virus spread in these cultures was not observed. In contrast, macrophages from BALB/c or C57BL/6 IFNAR -/mice were highly permissive to EBOV GP/rVSV and IFNγ treatment of these cells profoundly decreased infection in a dose dependent manner (S3A and S3B Fig) . Hence, we used peritoneal macrophages from IFNAR -/mice in subsequent studies with EBOV GP/rVSV.
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