Selected article for: "host protease and virus ability"
Author: Lee, Sanghyun; Baldridge, Megan T.
Title: Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections
  • Document date: 2017_6_30
    • ID: 0bz297i0_15
    Snippet: Identifying viral antagonists of host pathways can highlight critical antiviral host pathways. MNoV antagonizes IFNs via a protein expressed from ORF4, VF1, which in vitro delays upregulation of innate genes including type I IFNs (69) . MNoV has also been shown to diminish the host response to infection via its protease NS6, which specifically suppresses host ISG translation (70) . However, the interactions of these genes with IFN-λ signaling in.....
    Document: Identifying viral antagonists of host pathways can highlight critical antiviral host pathways. MNoV antagonizes IFNs via a protein expressed from ORF4, VF1, which in vitro delays upregulation of innate genes including type I IFNs (69) . MNoV has also been shown to diminish the host response to infection via its protease NS6, which specifically suppresses host ISG translation (70) . However, the interactions of these genes with IFN-λ signaling in the intestine have not yet been explored. A final potential viral player of interest is MNoV NS1/2. A single amino acid difference in this gene confers the ability of the virus to persist in the intestine and stool (65) . It is a tempting speculation that intestinal viral persistence requires antagonism of IFN-λ, but further studies are needed to determine whether NoV has evolved to avoid the antiviral effects of this signaling pathway.

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