Author: Kumar, Satyendra; Arankalle, Vidya A.
Title: Intracranial Administration of P Gene siRNA Protects Mice from Lethal Chandipura Virus Encephalitis Document date: 2010_1_7
ID: 1mzq227n_45
Snippet: In another experiment, the virus dose was reduced to 10 LD 50. Mice received one (simultaneous) or two doses (0 and 24hr) of 5 ug P-2 siRNA. In the first group, the animals showed extended survival by 48 hr (,60% mice) followed by survival of one mouse (10%, (p,0.001). Importantly, ,70% survival was recorded in mice receiving two doses of P-2 siRNA (p,0.0001) (Fig 7b) . In accordance with the extended survival, the viral titres in the brain tissu.....
Document: In another experiment, the virus dose was reduced to 10 LD 50. Mice received one (simultaneous) or two doses (0 and 24hr) of 5 ug P-2 siRNA. In the first group, the animals showed extended survival by 48 hr (,60% mice) followed by survival of one mouse (10%, (p,0.001). Importantly, ,70% survival was recorded in mice receiving two doses of P-2 siRNA (p,0.0001) (Fig 7b) . In accordance with the extended survival, the viral titres in the brain tissue from mice treated with two doses of P-2 siRNA were reduced by 4logs as compared to the control group (p,0.00031) (Fig 8) .
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