Author: Kumar, Satyendra; Arankalle, Vidya A.
Title: Intracranial Administration of P Gene siRNA Protects Mice from Lethal Chandipura Virus Encephalitis Document date: 2010_1_7
ID: 1mzq227n_52
Snippet: Following the recognition of emergence of CHPV as an emerging pathogen causing rapid and high mortality in children in India, being the national institute and considering restricted spread of the virus, we undertook two approaches as probable strategies to combat the infection, development of a prophylactic vaccine [28] and siRNA administration as a probable therapeutic agent (present study). We were able to identify a potent siRNA that could pro.....
Document: Following the recognition of emergence of CHPV as an emerging pathogen causing rapid and high mortality in children in India, being the national institute and considering restricted spread of the virus, we undertook two approaches as probable strategies to combat the infection, development of a prophylactic vaccine [28] and siRNA administration as a probable therapeutic agent (present study). We were able to identify a potent siRNA that could protect mice from the lethal encephalitis even when the virus was directly introduced in the target organ, the brain.
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