Author: Singh, Manmeet; Khan, Reas S.; Dine, Kimberly; Das Sarma, Jayasri; Shindler, Kenneth S.
Title: Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis Document date: 2018_9_4
ID: 03c9rx3o_7
Snippet: We hypothesized that RSA59 can be used to induce optic neuritis when inoculated intranasally at lower doses than required to induce brain and spinal cord disease due to enhanced viral spread to optic nerve. Mice were inoculated with RSA59 and RSMHV2 as control, both intranasally as well as intracranially at equivalent concentrations to compare if both routes of administration result in the same optic nerve pathology......
Document: We hypothesized that RSA59 can be used to induce optic neuritis when inoculated intranasally at lower doses than required to induce brain and spinal cord disease due to enhanced viral spread to optic nerve. Mice were inoculated with RSA59 and RSMHV2 as control, both intranasally as well as intracranially at equivalent concentrations to compare if both routes of administration result in the same optic nerve pathology.
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