Author: Xu, Yingying; Yuen, Pak-Wai; Lam, Jenny Ka-Wing
Title: Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Document date: 2014_7_10
ID: 0bma2749_7
Snippet: Although persistent antigen expression of DNA vaccine is usually expected to provide long-term immune protection against infectious diseases, the effect of sustained expression of antigen must be carefully examined and controlled. It has been reported that prolonged expression of antigen may lead to the switch of type-1 IFN from an antiviral cytokine to an immunosuppressive cytokine [26] , or may deplete the pool of memory T cells [27] ......
Document: Although persistent antigen expression of DNA vaccine is usually expected to provide long-term immune protection against infectious diseases, the effect of sustained expression of antigen must be carefully examined and controlled. It has been reported that prolonged expression of antigen may lead to the switch of type-1 IFN from an antiviral cytokine to an immunosuppressive cytokine [26] , or may deplete the pool of memory T cells [27] .
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