Selected article for: "Inv generate and pseudoknot structure"
Author: Gao, James ZM; Li, Linda YM; Reidys, Christian M
Title: Inverse folding of RNA pseudoknot structures
  • Document date: 2010_6_23
    • ID: 1lojd0xa_80
    Snippet: As discussed in the introduction it has to be given an argument as to why the inverse folding of pseudoknot RNA structures works. While folding maps into RNA secondary structures are well understood, the generalization to 3-noncrossing RNA structures is nontrivial. However the combinatorics of RNA pseudoknot structures [27, 28, 38] implies the existence of large neutral networks, i.e. networks composed by sequences that all fold into a specific p.....
    Document: As discussed in the introduction it has to be given an argument as to why the inverse folding of pseudoknot RNA structures works. While folding maps into RNA secondary structures are well understood, the generalization to 3-noncrossing RNA structures is nontrivial. However the combinatorics of RNA pseudoknot structures [27, 28, 38] implies the existence of large neutral networks, i.e. networks composed by sequences that all fold into a specific pseudoknot structure. Therefore, the fact that it is indeed possible to generate via Inv sequences contained in the neutral networks of targets against competing pseudoknot configurations, see Figure 24 and Figure 25 confirms the predictions of [31] .

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