Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets Document date: 2019_7_9
ID: 100r7w2n_114
Snippet: We determine whether HLA alleles with similar sequences, or drug with similar modes of action lead to selection responses that are similar. To obtain dendrograms of drug selection profiles and HLA selection profiles we first assign estimated per-site selection coefficients to one of four broad classes, based on the median of the selection profile at that site:.....
Document: We determine whether HLA alleles with similar sequences, or drug with similar modes of action lead to selection responses that are similar. To obtain dendrograms of drug selection profiles and HLA selection profiles we first assign estimated per-site selection coefficients to one of four broad classes, based on the median of the selection profile at that site:
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