Selected article for: "reverse protease and sequence ambiguity"
Author: Palmer, Duncan S.; Turner, Isaac; Fidler, Sarah; Frater, John; Goedhals, Dominique; Goulder, Philip; Huang, Kuan-Hsiang Gary; Oxenius, Annette; Phillips, Rodney; Shapiro, Roger; Vuuren, Cloete van; McLean, Angela R.; McVean, Gil
Title: Mapping the drivers of within-host pathogen evolution using massive data sets
  • Document date: 2019_7_9
    • ID: 100r7w2n_98
    Snippet: We removed ambiguous codons and sequences from both the protease and reverse transcriptase alignments by first deleting codons with > 5% ambiguity and then sequences with > 5% sequence ambiguity as in our data set prepartion for the drug associated selection analysis. Removal of sequence ambiguity resulted in a total of 162, 901 and 184, 817 reference sequences for protease and reverse transcriptase respectively......
    Document: We removed ambiguous codons and sequences from both the protease and reverse transcriptase alignments by first deleting codons with > 5% ambiguity and then sequences with > 5% sequence ambiguity as in our data set prepartion for the drug associated selection analysis. Removal of sequence ambiguity resulted in a total of 162, 901 and 184, 817 reference sequences for protease and reverse transcriptase respectively.

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