Author: Paesen, Guido C.; Collet, Axelle; Sallamand, Corinne; Debart, Françoise; Vasseur, Jean-Jacques; Canard, Bruno; Decroly, Etienne; Grimes, Jonathan M.
Title: X-ray structure and activities of an essential Mononegavirales L-protein domain Document date: 2015_11_9
ID: 1taxqkk2_8
Snippet: Mutagenesis studies show that all K-D-K-E residues (K 1673 , D 1779 , K 1817 and E 1848 ) are essential for 2 0 O-methylation, while the aspartic acid (D 1779 ) in particular is important for N7-methylation (Fig. 3b) , as was also observed in Flaviviridae MTases 9 . Other residues, many of which belong to the þ domain rather than the core MTase fold, were also found to be essential for the MTase activities (the ' SUB P' residues in Fig. 3b , des.....
Document: Mutagenesis studies show that all K-D-K-E residues (K 1673 , D 1779 , K 1817 and E 1848 ) are essential for 2 0 O-methylation, while the aspartic acid (D 1779 ) in particular is important for N7-methylation (Fig. 3b) , as was also observed in Flaviviridae MTases 9 . Other residues, many of which belong to the þ domain rather than the core MTase fold, were also found to be essential for the MTase activities (the ' SUB P' residues in Fig. 3b , described below).
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