Author: Ojosnegros, Samuel; Beerenwinkel, Niko
Title: Models of RNA virus evolution and their roles in vaccine design Document date: 2010_11_3
ID: 0q928h3b_9
Snippet: In general, the study of correlated evolution among genotypic and phenotypic traits or between traits and the environment across species is known as the comparative method [23] . It has been extremely successful in analyzing DNA sequence data and it is the basis for predicting phenotypes, such as protein structure or function, from genotypes. In the case of RNA viruses, which display a large genetic diversity between hosts, the different viral qu.....
Document: In general, the study of correlated evolution among genotypic and phenotypic traits or between traits and the environment across species is known as the comparative method [23] . It has been extremely successful in analyzing DNA sequence data and it is the basis for predicting phenotypes, such as protein structure or function, from genotypes. In the case of RNA viruses, which display a large genetic diversity between hosts, the different viral quasispecies take the role of the different species in the traditional application of the comparative method. Viral phenotypes of interest include immunological escape and drug resistance.
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