Author: Zivcec, Marko; Scholte, Florine E. M.; Spiropoulou, Christina F.; Spengler, Jessica R.; Bergeron, Éric
Title: Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus Document date: 2016_4_21
ID: 0a20s62q_17
Snippet: Our understanding of CCHFV assembly and egress is limited. Like other bunyaviruses, CCHFV RNPs are most likely found in the cytoplasm, and NP is localized in the perinuclear region close to the Golgi complex [61] . The subcellular localization of the viral glycoproteins often dictates the location of virus budding; the accumulation of the glycoproteins in the Golgi complex and TGN [37, 54] and NP in perinuclear regions is compatible with budding .....
Document: Our understanding of CCHFV assembly and egress is limited. Like other bunyaviruses, CCHFV RNPs are most likely found in the cytoplasm, and NP is localized in the perinuclear region close to the Golgi complex [61] . The subcellular localization of the viral glycoproteins often dictates the location of virus budding; the accumulation of the glycoproteins in the Golgi complex and TGN [37, 54] and NP in perinuclear regions is compatible with budding and assembly of CCHFV particles in the Golgi complex and/or TGN. [61, 62] . Following assembly, CCHFV particles are released by exocytosis often in the absence of discernable cytopathology and egress occurs from the basolateral membrane in polarized epithelial cells [63] .
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