Author: Andrews, Denise; Chetty, Yumela; Cooper, Ben S.; Virk, Manjinder; Glass, Stephen K; Letters, Andrew; Kelly, Philip A.; Sudhanva, Malur; Jeyaratnam, Dakshika
Title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use Document date: 2017_10_10
ID: 1sdt9zz8_21
Snippet: The power calculation was based upon length of stay, which had previously been observed to be 3.2 days on the study wards. Rapid pathogen identification has been associated with a reduction of mean hospital length of stay, in one study from 11.9 days to 9.3 days (approx. 20%) (p = 0.1) [17] . For a 20% reduction in length of stay (LOS) in the intervention arm, sample size calculations indicated that sample sizes of 1131 cases in each arm were req.....
Document: The power calculation was based upon length of stay, which had previously been observed to be 3.2 days on the study wards. Rapid pathogen identification has been associated with a reduction of mean hospital length of stay, in one study from 11.9 days to 9.3 days (approx. 20%) (p = 0.1) [17] . For a 20% reduction in length of stay (LOS) in the intervention arm, sample size calculations indicated that sample sizes of 1131 cases in each arm were required to achieve 90% power to detect a difference of 0.6 between the null hypothesis that both group means are 3.2 days (76.8 h, based upon data collected from the study wards) and the alternative hypothesis that the mean of group 2 is 2.6 days (62.4 h) with known group standard deviations of 5.2 and 5.2 and with a significance level (alpha) of 0.05.
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