Selected article for: "constant mutation rate model and mutation rate model"
Author: Vega, Vinsensius B; Ruan, Yijun; Liu, Jianjun; Lee, Wah Heng; Wei, Chia Lin; Se-Thoe, Su Yun; Tang, Kin Fai; Zhang, Tao; Kolatkar, Prasanna R; Ooi, Eng Eong; Ling, Ai Ee; Stanton, Lawrence W; Long, Philip M; Liu, Edison T
Title: Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003
  • Document date: 2004_9_6
    • ID: 0gmtnkbh_33
    Snippet: We obtained the precise dates of symptom onset of 13 Singaporean cases (Table S1 ). Using the common mutations identified through application of the mutation filter, we employed the constant mutation rate model and estimated the mutation rate of the SARS-CoV during this recent epidemic. We estimated the mutation rate to be 0.1722 nucleotides per day, or 5.7 × 10 -6 nucleotide substitutions per site per day (adjusted R-square value of the fitted .....
    Document: We obtained the precise dates of symptom onset of 13 Singaporean cases (Table S1 ). Using the common mutations identified through application of the mutation filter, we employed the constant mutation rate model and estimated the mutation rate of the SARS-CoV during this recent epidemic. We estimated the mutation rate to be 0.1722 nucleotides per day, or 5.7 × 10 -6 nucleotide substitutions per site per day (adjusted R-square value of the fitted model = 0.4014). The rates for synonymous and non-synonymous mutations were equivalent at 2.5 × 10 -6 and 3.2 × 10 -6 nucleotide substitutions per site per day respectively. Using the Singapore isolates with known date of onset, and using the SZ3 and SZ16 genomes isolated from palm civet cat [12] as the putative "original" SARS-CoV that jumped from animal to human, we calcu- Overall, the mutation rate of SARS-CoV appears to be consistent with the reported rate of other viruses [13, 14] .

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