Author: Ferreira, Anderson J.; Murça, Tatiane M.; Fraga-Silva, Rodrigo A.; Castro, Carlos Henrique; Raizada, Mohan K.; Santos, Robson A. S.
Title: New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis Document date: 2012_1_26
ID: 0qkzd2w4_5
Snippet: The heart is one of the most important targets for the actions of the ACE2/Ang-(1-7)/Mas axis. In the heart, ACE2 International Journal of Hypertension 3 is expressed in the endothelium [45] , myofibroblasts [46] , cardiomyocytes, and fibroblasts [47, 48] . Classical pharmacotherapeutic agents used to treat heart failure, including ACEi, ARBs, and aldosterone receptor blockers, increase ACE2 activity and/or expression, indicating its importance i.....
Document: The heart is one of the most important targets for the actions of the ACE2/Ang-(1-7)/Mas axis. In the heart, ACE2 International Journal of Hypertension 3 is expressed in the endothelium [45] , myofibroblasts [46] , cardiomyocytes, and fibroblasts [47, 48] . Classical pharmacotherapeutic agents used to treat heart failure, including ACEi, ARBs, and aldosterone receptor blockers, increase ACE2 activity and/or expression, indicating its importance in the cardiac diseases establishment and progression [49] [50] [51] .
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