Author: Hsu, Shih-Hsien; Yeh, Ming-Lun; Wang, Shen-Nien
Title: New Insights in Recurrent HCV Infection after Liver Transplantation Document date: 2013_4_23
ID: 0hbeso65_38
Snippet: Using a functional RNAi kinase screen, recent study identified epidermal growth factor receptor (EGFR) and ephrin receptor A2 (EPHA2), two receptor tyrosine kinases (RTKs) which regulate a number of key cellular functions, as host factors for HCV entry [103] . The results showed that the identified RTKs mediated HCV entry by regulating CD81claudin-1 coreceptor associations and viral glycoproteindependent membrane fusion, implying that inhibition .....
Document: Using a functional RNAi kinase screen, recent study identified epidermal growth factor receptor (EGFR) and ephrin receptor A2 (EPHA2), two receptor tyrosine kinases (RTKs) which regulate a number of key cellular functions, as host factors for HCV entry [103] . The results showed that the identified RTKs mediated HCV entry by regulating CD81claudin-1 coreceptor associations and viral glycoproteindependent membrane fusion, implying that inhibition of RTK function may constitute a new approach for the prevention and treatment of HCV infection.
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