Author: Lunding, Lars; Wegmann, Michael
Title: NK cells in asthma exacerbation Document date: 2015_7_8
ID: 0v17xscr_4
Snippet: FACS analysis also revealed markedly enhanced numbers of IL-17A-producing natural killer (NK) cells, but not NK T cells, in the lungs of animals with experimental asthma exacerbation. Consequently, we depleted NK cells in these mice, which resulted not only in a reduction of IL-17A levels in broncho-alveolar lavage (BAL) fluid to the levels of the controls, but also ablated most hallmarks of acute asthma exacerbation [3]. These data suggest that .....
Document: FACS analysis also revealed markedly enhanced numbers of IL-17A-producing natural killer (NK) cells, but not NK T cells, in the lungs of animals with experimental asthma exacerbation. Consequently, we depleted NK cells in these mice, which resulted not only in a reduction of IL-17A levels in broncho-alveolar lavage (BAL) fluid to the levels of the controls, but also ablated most hallmarks of acute asthma exacerbation [3]. These data suggest that NK cells drive the inflammatory response underlying acute asthma exacerbation by producing IL-17A. Thus, these data implement NK cells for the first time into the pathogenesis of virus-induced asthma exacerbations.
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