Author: Wilkins, Jordan; Zheng, Yi-Min; Yu, Jingyou; Liang, Chen; Liu, Shan-Lu
Title: Nonhuman Primate IFITM Proteins Are Potent Inhibitors of HIV and SIV Document date: 2016_6_3
ID: 1m1woscb_1
Snippet: Following detection of pathogen-associated molecular patterns (PAMPs), cells produce and secrete interferon [1, 2] . Interferons are cytokines that upregulate the expression of hundreds of interferon-stimulated genes (ISGs) and represent one of the cells first lines of defense against viruses [3] . Several ISGs have been characterized with antiviral activity, including Tetherin, TRIM5α, APOBEC3G, SAMHD1, and MxB [4] [5] [6] [7] [8] [9] [10] [11].....
Document: Following detection of pathogen-associated molecular patterns (PAMPs), cells produce and secrete interferon [1, 2] . Interferons are cytokines that upregulate the expression of hundreds of interferon-stimulated genes (ISGs) and represent one of the cells first lines of defense against viruses [3] . Several ISGs have been characterized with antiviral activity, including Tetherin, TRIM5α, APOBEC3G, SAMHD1, and MxB [4] [5] [6] [7] [8] [9] [10] [11] . The interferon-induced transmembrane (IFITM) proteins are a subset of ISGs known to restrict several enveloped viruses including, but not limited to, influenza A virus (IAV), dengue virus, Ebola virus, SARS coronavirus, hepatitis C virus (HCV), Jaagsiekte sheep retrovirus (JSRV) and human immunodeficiency virus (HIV) [12] [13] [14] [15] [16] [17] [18] [19] .
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