Author: Marriott, Andrew S.; Vasieva, Olga; Fang, Yongxiang; Copeland, Nikki A.; McLennan, Alexander G.; Jones, Nigel J.
Title: NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap(4)A) and Down-Regulates Immune Response and Cancer Promotion Genes Document date: 2016_5_4
ID: 0ozzbp85_20
Snippet: The difference in gene expression profiles between the two cell types is illustrated in the Principal Component Analysis (PCA) plot of log2 gene expression data shown in Fig 2A. The triplicate samples of each cell type are grouped well away from each other, indicating a high degree of differential gene expression between them. Furthermore, the heatmap of the Pearson correlation coefficients in Fig 2B indicated that the expression profiles for the.....
Document: The difference in gene expression profiles between the two cell types is illustrated in the Principal Component Analysis (PCA) plot of log2 gene expression data shown in Fig 2A. The triplicate samples of each cell type are grouped well away from each other, indicating a high degree of differential gene expression between them. Furthermore, the heatmap of the Pearson correlation coefficients in Fig 2B indicated that the expression profiles for the three samples from the same cell type were much more closely correlated than samples from different cell types, showing that the effect of NUDT2 knockout on gene expression was much stronger than the influence of any technical or biological variations between samples. The heatmap also shows a very high correlation (R >0.99) among samples from the same cell type. Thus, we can conclude that the differential gene expression detected here is statistically very robust.
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