Author: Vittucci, Anna Chiara; Spuri Vennarucci, Valentina; Grandin, Annalisa; Russo, Cristina; Lancella, Laura; Tozzi, Albero Eugenio; Bartuli, Andrea; Villani, Alberto
Title: Pertussis in infants: an underestimated disease Document date: 2016_8_15
ID: 10xqdm7m_37
Snippet: The use of molecular assays has become standard of care in many setting recently. Mainly PCR has the advantage of offering result within several hours and in most of the cases, it is considerated highly sensitive especially during the "late stage" of the disease. Moreover, because is not affected by the use of drugs, one of the major usefulness respect to cultures methods is that specimens could be collected after antibiotic treatment has been st.....
Document: The use of molecular assays has become standard of care in many setting recently. Mainly PCR has the advantage of offering result within several hours and in most of the cases, it is considerated highly sensitive especially during the "late stage" of the disease. Moreover, because is not affected by the use of drugs, one of the major usefulness respect to cultures methods is that specimens could be collected after antibiotic treatment has been started. Phenotypic cultures, although highly specific, fall in sensitivity with a reported range between 30 and 60 % of BP detection and increased time for releasing test result compared with PCR [27] . We account as great limitation of PCR that it's unable to differentiate asymptomatic carriers. In our series, all the patients were admitted for acute respiratory symptoms and were unvaccinated so we considered them as affected by pertussis and to be properly treated.
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