Author: Hu, Aimin; Li, Junyu; Ruan, Shufang; Fan, Ying; Liao, Yuqian
Title: Polymorphisms in CLDN1 are associated with age and differentiation of triple-negative breast cancer patients Document date: 2019_4_23
ID: 106tex7s_5
Snippet: Peripheral blood samples (5 ml) were collected from each patient upon recruitment and stored in −20 • C for DNA extraction. Genotype data from CLDN1 gene regions encompassing 5 kb of upstream and 5 kb of downstream flanking sequences were extracted from the HapMap Chinese Han population. Haploview 4.2 software was used to identify Tag single nucleotide polymorphisms (SNPs). The inclusion criteria were SNPs known in ethnic Han Chinese populati.....
Document: Peripheral blood samples (5 ml) were collected from each patient upon recruitment and stored in −20 • C for DNA extraction. Genotype data from CLDN1 gene regions encompassing 5 kb of upstream and 5 kb of downstream flanking sequences were extracted from the HapMap Chinese Han population. Haploview 4.2 software was used to identify Tag single nucleotide polymorphisms (SNPs). The inclusion criteria were SNPs known in ethnic Han Chinese population and with a minor allele frequency (MAF) >0.05 and r 2 > 0.8. A total of five candidate SNPs were selected for genotyping (Table 1) . Primers and probes were designed by MassARRAY Typer 4.0 software. MassARRAY MALDI-TOF System (Sequenom Inc., San Diego, CA, U.S.A.) [18, 19] was used for genotyping by the method described in the Sequenom Genotyping Protocol.
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