Selected article for: "blood monocyte and peripheral blood"
Author: Wang, Xiuqing; Christopher-Hennings, Jane
Title: Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells
  • Document date: 2012_5_2
    • ID: 1jmhvclq_10
    Snippet: PRRSV activates the transcription of type I interferon in porcine alveolar macrophages, peripheral blood mononuclear cells, and monocyte-derived dendritic cells. However, PRRSV interferes with the translation of type I interferon in these cells partly through cytopathogenicity since UV and heat-inactivated viruses lose their ability to interfere with the induction of type I interferon by porcine transmissible gastroenteritis virus or Poly I:C. Fu.....
    Document: PRRSV activates the transcription of type I interferon in porcine alveolar macrophages, peripheral blood mononuclear cells, and monocyte-derived dendritic cells. However, PRRSV interferes with the translation of type I interferon in these cells partly through cytopathogenicity since UV and heat-inactivated viruses lose their ability to interfere with the induction of type I interferon by porcine transmissible gastroenteritis virus or Poly I:C. Further studies are needed to delineate the exact mechanisms by which PRRSV interferes with the translation of type I interferon in its natural host cells.

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