Author: Muñoz-González, Sara; Ruggli, Nicolas; Rosell, Rosa; Pérez, Lester Josué; Frías-Leuporeau, Maria Teresa; Fraile, Lorenzo; Montoya, Maria; Cordoba, Lorena; Domingo, Mariano; Ehrensperger, Felix; Summerfield, Artur; Ganges, Llilianne
Title: Postnatal Persistent Infection with Classical Swine Fever Virus and Its Immunological Implications Document date: 2015_5_4
ID: 13cii3on_42
Snippet: Four weeks after infection, the PBMCs from the persistently infected and seronegative piglets were unresponsive to both specific CSFV and non-specific PHA stimulation, in terms of IFN-γ producing cells. On the contrary, the three piglets that cleared the virus and seroconverted responded equally well to CSFV and PHA stimulation. PHA and Concanavalin A have been used previously to characterise the general functionality of the cellular immune resp.....
Document: Four weeks after infection, the PBMCs from the persistently infected and seronegative piglets were unresponsive to both specific CSFV and non-specific PHA stimulation, in terms of IFN-γ producing cells. On the contrary, the three piglets that cleared the virus and seroconverted responded equally well to CSFV and PHA stimulation. PHA and Concanavalin A have been used previously to characterise the general functionality of the cellular immune response in the context of acute and persistent CSFV infections. After acute CSFV infections, the responses of PBMC to mitogens were also partly or completely impaired, indicating general transient immunosuppression [32, 42, 61] . In contrast, with trans-placental infections, immunotolerant pigs showed a normal lymphocyte response to PHA, indeed suggesting specific immunotolerance, rather than general immunosuppression [21, 62, 63] .
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