Recombinant Lactobacillus casei Expressing Capsid Protein VP60 can Serve as Vaccine Against Rabbit Hemorrhagic Disease Virus in Rabbits

Wang, Li; Xia, Tian; Guo, Tiantian; Ru, Yi; Jiang, Yanping; Cui, Wen; Zhou, Han; Qiao, Xinyuan; Tang, Lijie; Xu, Yigang; Li, Yijing

The liver, spleen, and small intestine, collected from the rabbits in different treatment groups, were subjected to histopathological evaluation. Lesions on liver, spleen, and small intestine were more severe in the PBS-treated group than in the vaccinated groups. In the PBS-treated group, the hepatocytes in the liver presented a disordered appearance and clearly manifested degeneration and necrosis. Splenic corpuscles appeared destroyed, and some had disappeared entirely, splenic sinus was congested, and intestine villi were necrotic and severely desquamated. There are almost no differences between the pPG-eGFP-VP60/LC393-immunized group and inactivated vaccine-immunized group (Figure 8 ).