Author: Kuban-Jankowska, Alicja; Sahu, Kamlesh K; Niedzialkowski, Pawel; Gorska, Magdalena; Tuszynski, Jack A; Ossowski, Tadeusz; Wozniak, Michal
Title: Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis Document date: 2015_7_22
ID: 1irvzt8v_5
Snippet: The catalytic center of the YopH contains an amino acid sequence similar to eukaryotic protein tyrosine phosphatases (PTPs). There is a cysteine residue located at the bottom of the active site, which is essential for catalysis and enzymatic activity [8] . As for the eukaryotic PTP family, the catalytic cysteine is highly vulnerable to oxidation, which results in inactivation of the enzyme and depends on the oxidation state leads to formation in .....
Document: The catalytic center of the YopH contains an amino acid sequence similar to eukaryotic protein tyrosine phosphatases (PTPs). There is a cysteine residue located at the bottom of the active site, which is essential for catalysis and enzymatic activity [8] . As for the eukaryotic PTP family, the catalytic cysteine is highly vulnerable to oxidation, which results in inactivation of the enzyme and depends on the oxidation state leads to formation in the active site, respectively, of an irreversible sulfenic acid residue or irreversible sulfinic and sulfonic acid residues [9] .
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