Selected article for: "adar specific and adenosine deaminase"
Author: Stepanov, Grigory A.; Filippova, Julia A.; Komissarov, Andrey B.; Kuligina, Elena V.; Richter, Vladimir A.; Semenov, Dmitry V.
Title: Regulatory Role of Small Nucleolar RNAs in Human Diseases
  • Document date: 2015_4_28
    • ID: 0ws5q37g_14
    Snippet: ACA11 is a peculiar snoRNA encoded within an intron of WHSC1 that exhibits the structure of a box H/ACA RNA and is predominantly localized in the nucleolus [41] . However, it has been demonstrated that it does not associate with dyskerin and other components of the pseudouridylation machinery typical of H/ACA snoRNPs. Instead, it binds to the proteins implicated in RNA processing: RNA splicing factors (SF3B1, SF3B2, and SFPQ), ATP-dependent RNA h.....
    Document: ACA11 is a peculiar snoRNA encoded within an intron of WHSC1 that exhibits the structure of a box H/ACA RNA and is predominantly localized in the nucleolus [41] . However, it has been demonstrated that it does not associate with dyskerin and other components of the pseudouridylation machinery typical of H/ACA snoRNPs. Instead, it binds to the proteins implicated in RNA processing: RNA splicing factors (SF3B1, SF3B2, and SFPQ), ATP-dependent RNA helicase A (DHX9), RNA-specific adenosine deaminase (ADAR), and the members of the heterogeneous nuclear ribonucleoprotein family. ACA11 is highly expressed in multiple myeloma, colon, esophageal, and bladder cancers. ACA11 overexpression was found to induce downregulation of ribosomal protein genes and snRNA involved in oxidative stress regulation, resulting in resistance to chemotherapy and enhancing multiple myeloma cell proliferation [41] .

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