Author: Ahanchian, Hamid; Jones, Carmen M; Chen, Yueh-sheng; Sly, Peter D
Title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? Document date: 2012_9_13
ID: 0mnsm6s4_54
Snippet: The monoclonal antibody to the cellular ICAM-1 was not effective. CFY196 (Coldsol) is a nasal spray multivalent Fab fusion proteins against ICAM-1 with a better avidity and in vitro potency against HRV [178] . Tremacamra, a soluble intercellular adhesion molecule 1 reduced the severity of experimental rhinovirus infection [179] . Pleconaril, an orally administered antiviral drug, acts by binding to a hydrophobic pocket in viral protein 1, and sta.....
Document: The monoclonal antibody to the cellular ICAM-1 was not effective. CFY196 (Coldsol) is a nasal spray multivalent Fab fusion proteins against ICAM-1 with a better avidity and in vitro potency against HRV [178] . Tremacamra, a soluble intercellular adhesion molecule 1 reduced the severity of experimental rhinovirus infection [179] . Pleconaril, an orally administered antiviral drug, acts by binding to a hydrophobic pocket in viral protein 1, and stabilizes the protein capsid so that the virus cannot release its RNA genome into the target cell. Outcomes of clinical trials with pleconaril have revealed mixed results and new compounds are currently being developed [180] .
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