Author: Hershenson, Marc B.
Title: Rhinovirus-Induced Exacerbations of Asthma and COPD Document date: 2013_2_21
ID: 1kdc6xk8_22
Snippet: Returning to the question of antiviral innate immunity in asthma, we also employed our animal model to address this issue. Does the inflammatory response to rhinovirus promote viral clearance and prevent more severe viral-induced disease? Or is the inflammatory response to rhinovirus a maladaptive response to an innocuous stimulus, leading to exacerbations of lower airways disease? These questions have important ramifications for treatment. One o.....
Document: Returning to the question of antiviral innate immunity in asthma, we also employed our animal model to address this issue. Does the inflammatory response to rhinovirus promote viral clearance and prevent more severe viral-induced disease? Or is the inflammatory response to rhinovirus a maladaptive response to an innocuous stimulus, leading to exacerbations of lower airways disease? These questions have important ramifications for treatment. One often hears the statement that individuals "need to boost their immune response" to fight off colds or cold-induced asthma attacks. The Imperial College group has championed the idea that the interferon response is deficient in asthmatics [64, 65] , thereby explaining viral-induced exacerbations. In this case, boosting of the immune response with interferons might be helpful.
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