Selected article for: "cognate codon and frame codon"
Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
  • Document date: 2016_9_6
    • ID: 0s8huajd_112
    Snippet: Bacterial release factor 2 (RF2) mediates termination at UGA and UAA, with its termination at UGA being unique since bacterial release factor 1 mediates termination at UAG and UAA. Before their genes were sequenced the possibility was entertained that the coding sequence for RF2 might have an in-frame UGA stop codon early in the coding sequence with deficiency of RF2 leading to extra slow decoding of UGA that facilitated stop codon readthrough by.....
    Document: Bacterial release factor 2 (RF2) mediates termination at UGA and UAA, with its termination at UGA being unique since bacterial release factor 1 mediates termination at UAG and UAA. Before their genes were sequenced the possibility was entertained that the coding sequence for RF2 might have an in-frame UGA stop codon early in the coding sequence with deficiency of RF2 leading to extra slow decoding of UGA that facilitated stop codon readthrough by near-cognate tRNA resulting in synthesis of full-length RF2. However, none of the RF2 genes from the large number of sequenced bacterial genes have such an early in-frame UGA codon (348) with ORF2 continuing in the same frame and the counterpart with UAG and release factor 1 genes is also unknown. [A giant virus of amoeba does have a release factor gene whose expression involves stop codon readthrough and separately ribosomal frameshifting (349) .]

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