Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_147
Snippet: Certain C-terminal amino acid sequences, e.g. in bacteria Asp-Pro, contribute to an unusually long pause at termination, and some combinations, also involving proline, have marked effects during the elongation phase of protein synthesis (459) . While prolonged pausing in bacterial decoding can facilitate ribosome rescue by tmRNA/SmpB and ArfA, it is not in direct competition with the frameshifting (or readthrough) that pausing can also facilitate.....
Document: Certain C-terminal amino acid sequences, e.g. in bacteria Asp-Pro, contribute to an unusually long pause at termination, and some combinations, also involving proline, have marked effects during the elongation phase of protein synthesis (459) . While prolonged pausing in bacterial decoding can facilitate ribosome rescue by tmRNA/SmpB and ArfA, it is not in direct competition with the frameshifting (or readthrough) that pausing can also facilitate (460) . While the pausing aspects are considered below, the relevant fact here is that amino acid identity and not just shift site: anticodon interactions, can be important.
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