Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_254
Snippet: Various facets of programmed frameshifting and other types of recoding are likely to feature in the toolkit of future synthetic biology. However, for now the main excitement is the prospect of being able to ascertain the extent to which productive frameshifting is utilized to enrich gene expression and, with the recent advances in biophysical techniques, to at last understand how ribosomes sense and respond to recoding signals. In conclusion the .....
Document: Various facets of programmed frameshifting and other types of recoding are likely to feature in the toolkit of future synthetic biology. However, for now the main excitement is the prospect of being able to ascertain the extent to which productive frameshifting is utilized to enrich gene expression and, with the recent advances in biophysical techniques, to at last understand how ribosomes sense and respond to recoding signals. In conclusion the study of frameshifting has matured by reaching the final stage of Jonas Salk's 1958 trajectory for scientific discoveries: The way an idea eventually becomes an accepted truth is revealed by the stages through which it passes: First, it is said that 'It can't be true'; then, 'If true, it is not very important'; and finally, ' We knew it all along.' UGA-C.
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