Author: Atkins, John F.; Loughran, Gary; Bhatt, Pramod R.; Firth, Andrew E.; Baranov, Pavel V.
Title: Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use Document date: 2016_9_6
ID: 0s8huajd_50
Snippet: The sequence of the single-stranded RNA genome of hepatitis C virus that encodes a large polyprotein precursor has within it an alternative reading frame that specifies a product that has been linked to liver cancer, although it remains controversial as to whether the product is functionally relevant to virus growth or simply a manifestation of translational noise. A role for ribosomal frameshifting (177) or transcriptional slippage (178) in expr.....
Document: The sequence of the single-stranded RNA genome of hepatitis C virus that encodes a large polyprotein precursor has within it an alternative reading frame that specifies a product that has been linked to liver cancer, although it remains controversial as to whether the product is functionally relevant to virus growth or simply a manifestation of translational noise. A role for ribosomal frameshifting (177) or transcriptional slippage (178) in expression of the alternative product has been discussed. However, much evidence now favors internal initiation (179) , though more than one mechanism may contribute to synthesis of the 'extra' product.
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