Author: Wang, Tian; Welte, Thomas
Title: Role of Natural Killer and Gamma-Delta T cells in West Nile Virus Infection Document date: 2013_9_20
ID: 1udcd28n_16
Snippet: A major risk factor for fatality due to WNV infection in humans is aging [65, 66] . Aged mice were more susceptible to WNV infection than young adult mice [56, 67] . Vï§1 + cells of aged mice displayed a slower, reduced response to WNV infection compared to those of young adult mice, suggesting dysfunction of ï§ï¤ï€ T cells contribute to host susceptibility to WNV encephalitis [56] . Immunotherapy can improve the anti-tumor effect of ï§ï¤ï€ .....
Document: A major risk factor for fatality due to WNV infection in humans is aging [65, 66] . Aged mice were more susceptible to WNV infection than young adult mice [56, 67] . Vï§1 + cells of aged mice displayed a slower, reduced response to WNV infection compared to those of young adult mice, suggesting dysfunction of ï§ï¤ï€ T cells contribute to host susceptibility to WNV encephalitis [56] . Immunotherapy can improve the anti-tumor effect of ï§ï¤ï€ T cells [68, 69] . In one study [70] , oral administration of active hexose correlated compound (AHCC), an extract of Lentinula edodes of the Basidiomycete family of fungi rich in ï¡-glucans, enhanced the protective Vï§1 + T cell response and thus attenuated viremia in aged mice following lethal WNV infection.
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