Author: Sun, Di; Chen, Shun; Cheng, Anchun; Wang, Mingshu
Title: Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells Document date: 2016_3_17
ID: 07nfb69o_57
Snippet: Some extracts of plants and microbes have also been found to inhibit the proteolytic activity of 3C pro . As a member of the pyanonaphthoquinone family, the natural product (´)-thysanone has been reported to inhibit HRV 3C pro with an IC 50 value of 47 µM [146] . Through synthesis of analogues and the biological evaluation of (´)-thysanone, the 2-methylene analogue of (´)-thysanone has lost the capacity to inhibit HRV 3C pro [147] . However, .....
Document: Some extracts of plants and microbes have also been found to inhibit the proteolytic activity of 3C pro . As a member of the pyanonaphthoquinone family, the natural product (´)-thysanone has been reported to inhibit HRV 3C pro with an IC 50 value of 47 µM [146] . Through synthesis of analogues and the biological evaluation of (´)-thysanone, the 2-methylene analogue of (´)-thysanone has lost the capacity to inhibit HRV 3C pro [147] . However, 9-deoxy analogues of (´)-thysanone display better inhibitory ability than the natural product [148] . Studies of herbs have demonstrated that flavonoids, such as fisetin and rutin, can inhibit the enzymatic activity of EV 71 3C pro in a dose-dependent manner with IC 50 values of 85 and 110 µM, respectively [149] .
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