Author: Shi, Chong-Shan; Nabar, Neel R.; Huang, Ning-Na; Kehrl, John H.
Title: SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes Document date: 2019_6_5
ID: 0fpa1f30_14
Snippet: In NLRP3 expressing cells, signals that activate the NLRP3 inflammasomes cause the disassembly of the trans-Golgi network (TGN) and the recruitment of NLRP3 to the dispersed TGN, which serves as a scaffold for NLRP3 aggregation 35 . This leads to the polymerization of the adapter protein ASC and recruitment of caspase-1......
Document: In NLRP3 expressing cells, signals that activate the NLRP3 inflammasomes cause the disassembly of the trans-Golgi network (TGN) and the recruitment of NLRP3 to the dispersed TGN, which serves as a scaffold for NLRP3 aggregation 35 . This leads to the polymerization of the adapter protein ASC and recruitment of caspase-1.
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