Author: Guo, Jiao; Jia, Xiaoying; Liu, Yang; Wang, Shaobo; Cao, Junyuan; Zhang, Bo; Xiao, Gengfu; Wang, Wei
Title: Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection Document date: 2020_2_21
ID: 161ck1i9_7
Snippet: Ouabain and digoxin inhibit JEV infection during viral RNA synthesis. To determine the cellular process that these drugs target, a time-of-addition experiment was performed (Fig. 4A ). As shown in Fig. 4B , neither digoxin nor ouabain showed suppression of JEV in virucidal treatments or pretreatments. However, ouabain showed a robust inhibition of JEV during treatment. Most importantly, when added posttreatment, both ouabain and digoxin exerted f.....
Document: Ouabain and digoxin inhibit JEV infection during viral RNA synthesis. To determine the cellular process that these drugs target, a time-of-addition experiment was performed (Fig. 4A ). As shown in Fig. 4B , neither digoxin nor ouabain showed suppression of JEV in virucidal treatments or pretreatments. However, ouabain showed a robust inhibition of JEV during treatment. Most importantly, when added posttreatment, both ouabain and digoxin exerted full inhibitory effects on JEV infection, suggesting that viral replication was the main stage at which these drugs showed inhibitory activity.
Search related documents:
Co phrase search for related documents- addition time and drug target: 1, 2, 3
- addition time and inhibitory activity: 1, 2, 3, 4, 5, 6, 7, 8, 9
- addition time and inhibitory effect: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- addition time and JEV infection: 1, 2
- addition time experiment and inhibitory activity: 1
- addition time experiment and inhibitory effect: 1, 2, 3
- cellular process and drug target: 1, 2
- cellular process and inhibitory activity: 1, 2
- cellular process and inhibitory effect: 1
- digoxin ouabain and JEV infection: 1, 2, 3
- drug inhibitory activity show and inhibitory activity: 1
- drug inhibitory activity show and inhibitory activity show: 1
- drug target and inhibitory activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- drug target and inhibitory activity show: 1
- drug target and inhibitory effect: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- inhibitory activity and JEV infection: 1, 2
- inhibitory effect and JEV infection: 1
Co phrase search for related documents, hyperlinks ordered by date