Author: Guo, Jiao; Jia, Xiaoying; Liu, Yang; Wang, Shaobo; Cao, Junyuan; Zhang, Bo; Xiao, Gengfu; Wang, Wei
Title: Screening of Natural Extracts for Inhibitors against Japanese Encephalitis Virus Infection Document date: 2020_2_21
ID: 161ck1i9_7
Snippet: Ouabain and digoxin inhibit JEV infection during viral RNA synthesis. To determine the cellular process that these drugs target, a time-of-addition experiment was performed (Fig. 4A ). As shown in Fig. 4B , neither digoxin nor ouabain showed suppression of JEV in virucidal treatments or pretreatments. However, ouabain showed a robust inhibition of JEV during treatment. Most importantly, when added posttreatment, both ouabain and digoxin exerted f.....
Document: Ouabain and digoxin inhibit JEV infection during viral RNA synthesis. To determine the cellular process that these drugs target, a time-of-addition experiment was performed (Fig. 4A ). As shown in Fig. 4B , neither digoxin nor ouabain showed suppression of JEV in virucidal treatments or pretreatments. However, ouabain showed a robust inhibition of JEV during treatment. Most importantly, when added posttreatment, both ouabain and digoxin exerted full inhibitory effects on JEV infection, suggesting that viral replication was the main stage at which these drugs showed inhibitory activity.
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