Author: Pervushin, Konstantin; Tan, Edward; Parthasarathy, Krupakar; Lin, Xin; Jiang, Feng Li; Yu, Dejie; Vararattanavech, Ardcharaporn; Soong, Tuck Wah; Liu, Ding Xiang; Torres, Jaume
Title: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel Document date: 2009_7_10
ID: 1e102wrc_55
Snippet: The structure of the ETM monomer in DPC micelles was calculated using the site-specific assignment of 1 H, 13 C and 15 N resonances and unassigned NOEs as input for the program CYANA [62, 63] . Structure calculations started from 100 random conformers, using the standard simulated annealing protocol in CYANA. The statistics of meaningful NOE distance constraints in the final CYANA cycle (Table S1 ) showed a high density of structural constraints .....
Document: The structure of the ETM monomer in DPC micelles was calculated using the site-specific assignment of 1 H, 13 C and 15 N resonances and unassigned NOEs as input for the program CYANA [62, 63] . Structure calculations started from 100 random conformers, using the standard simulated annealing protocol in CYANA. The statistics of meaningful NOE distance constraints in the final CYANA cycle (Table S1 ) showed a high density of structural constraints per amino acid. Seven cycles of NOE assignment and structure reconstruction resulted in a bundle of 20 conformers with the average target function values below 0.15.
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