Selected article for: "ion channel and transmembrane domain"
Author: Pervushin, Konstantin; Tan, Edward; Parthasarathy, Krupakar; Lin, Xin; Jiang, Feng Li; Yu, Dejie; Vararattanavech, Ardcharaporn; Soong, Tuck Wah; Liu, Ding Xiang; Torres, Jaume
Title: Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
  • Document date: 2009_7_10
    • ID: 1e102wrc_6
    Snippet: In addition to the aforementioned roles of E protein in morphogenesis and tropism, enhanced membrane permeability has been observed in bacterial and mammalian cells expressing MHV E [33] or SARS-CoV E [34] . It has also been reported that synthetic E proteins of SARS-CoV, HCoV-229E, MHV, and IBV, have in vitro cation-selective ion channel activity in planar lipid bilayers, and this activity has been shown to be localized at the transmembrane doma.....
    Document: In addition to the aforementioned roles of E protein in morphogenesis and tropism, enhanced membrane permeability has been observed in bacterial and mammalian cells expressing MHV E [33] or SARS-CoV E [34] . It has also been reported that synthetic E proteins of SARS-CoV, HCoV-229E, MHV, and IBV, have in vitro cation-selective ion channel activity in planar lipid bilayers, and this activity has been shown to be localized at the transmembrane domain [35] [36] [37] . It was also shown that the drug hexamethylene amiloride (HMA), but not amiloride, inhibited in vitro conductance of synthetic MHV E and HCoV-229E E, and decreased viral replication of MHV and HCoV-229E in infected cells [36] .

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