Author: Boyington, Jeffrey C.; Joyce, M. Gordon; Sastry, Mallika; Stewart-Jones, Guillaume B. E.; Chen, Man; Kong, Wing-Pui; Ngwuta, Joan O.; Thomas, Paul V.; Tsybovsky, Yaroslav; Yang, Yongping; Zhang, Baoshan; Chen, Lei; Druz, Aliaksandr; Georgiev, Ivelin S.; Ko, Kiyoon; Zhou, Tongqing; Mascola, John R.; Graham, Barney S.; Kwong, Peter D.
Title: Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus Document date: 2016_7_27
ID: 1nbocmux_34
Snippet: The pre-F structure of the RSV F trimeric glycoprotein can be divided into two halves: a membrane-proximal half, the RSV F "stalk" region, which comprises domains I and II and has a primarily β-strand structure that terminates in a C-terminal coiled coil that enters the membrane; and a membrane-distal half, the RSV F "head" region, which comprises domain III and is primarily α-helical (Fig 1A and 1B) [9] . These two halves are connected by a lo.....
Document: The pre-F structure of the RSV F trimeric glycoprotein can be divided into two halves: a membrane-proximal half, the RSV F "stalk" region, which comprises domains I and II and has a primarily β-strand structure that terminates in a C-terminal coiled coil that enters the membrane; and a membrane-distal half, the RSV F "head" region, which comprises domain III and is primarily α-helical (Fig 1A and 1B) [9] . These two halves are connected by a long, two-stranded β-sheet, containing one strand from F 1 and another strand from F 2 . The RSV F head contains at least two epitopes associated with neutralizing antibodies.
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