Author: Fan, Qing; Kopp, Sarah J.; Connolly, Sarah A.; Longnecker, Richard
Title: Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype Document date: 2017_5_16
ID: 1v6nf28a_17
Snippet: The growth defects may be due to impaired and/or delayed cell-to-cell spread of gB 3A virus. In addition, defects in gB 3A egress also may contribute to its small-plaque phenotype and delayed growth. gB has been reported to function during virus egress and during both de-envelopment at the outer nuclear membrane and secondary envelopment (34, 35) . When the gB fusion loops were mutated, de-envelopment was impaired. The reduced fusion capacity of .....
Document: The growth defects may be due to impaired and/or delayed cell-to-cell spread of gB 3A virus. In addition, defects in gB 3A egress also may contribute to its small-plaque phenotype and delayed growth. gB has been reported to function during virus egress and during both de-envelopment at the outer nuclear membrane and secondary envelopment (34, 35) . When the gB fusion loops were mutated, de-envelopment was impaired. The reduced fusion capacity of gB 3A may hinder de-envelopment similarly.
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