Author: Fan, Qing; Kopp, Sarah J.; Connolly, Sarah A.; Longnecker, Richard
Title: Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype Document date: 2017_5_16
ID: 1v6nf28a_23
Snippet: Upon triggering, the gB 3A mutant may fold to a postfusion form that is inefficient at fusing membranes. Alternatively, the gB 3A mutations may alter the activation energy barriers that regulate the transitions between the prefusion, intermediate, and Infrequent or slow conversion of gB 3A from a prefusion to a postfusion conformation may account for the slow-penetration phenotype of the gB 3A virus. If the gB 3A mutations increase the activation.....
Document: Upon triggering, the gB 3A mutant may fold to a postfusion form that is inefficient at fusing membranes. Alternatively, the gB 3A mutations may alter the activation energy barriers that regulate the transitions between the prefusion, intermediate, and Infrequent or slow conversion of gB 3A from a prefusion to a postfusion conformation may account for the slow-penetration phenotype of the gB 3A virus. If the gB 3A mutations increase the activation energy required to trigger gB by either stabilizing the prefusion form (Fig. 10A) or destabilizing an intermediate conformation (Fig. 10B) , the rate of fusion would be decreased.
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