Author: Kouokam, Joseph Calvin; Lasnik, Amanda B.; Palmer, Kenneth E.
Title: Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses Document date: 2016_11_17
ID: 096348l5_1
Snippet: Despite recent advances in the development of new antiretrovirals, human immunodeficiency virus (HIV) continues to spread worldwide with an astonishing rate of approximately 5500 new infections a day [1] . HIV is a highly mutable virus and, thus, a major limitation of existing antiretrovirals is the ability of HIV to develop resistance under selective pressure from these drugs. This has led drug designers to opt for complementary combinations wit.....
Document: Despite recent advances in the development of new antiretrovirals, human immunodeficiency virus (HIV) continues to spread worldwide with an astonishing rate of approximately 5500 new infections a day [1] . HIV is a highly mutable virus and, thus, a major limitation of existing antiretrovirals is the ability of HIV to develop resistance under selective pressure from these drugs. This has led drug designers to opt for complementary combinations with high manufacturing costs, which makes delivery in resource-poor areas (where the disease burden is often highest) unfeasible [2] . Therefore, new, more efficient, and inexpensive antiviral drugs are needed in order to better combat HIV/AIDS. A few years ago, an anti-HIV bioassay guided fractionation of aqueous extracts of the
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