Beyond type 1 regulatory T cells: co-expression of LAG3 and CD49b in IL-10-producing T cell lineages

Weishan Huang; Sabrina Solouki; Chavez Carter; Song-Guo Zheng; Avery August

Foxp3 + CD4 + and CD8 + T cell subsets. The capacity of co-expression of LAG3 and CD49b 85 expression in marking IL-10 high T cell subsets is dependent on the disease conditions and 86 anatomical locations of the cells. Furthermore, co-expression of LAG3 and CD49b expression is 87 also a shared feature of human IL-10-producing FOXP3 -CD4 + , FOXP3 + CD4 + and CD8 + T cell 88 subsets. Our data reveal that co-expression of LAG3 and CD49b is a generic signature of IL-10-89 producing T cells, which is broader than previously appreciated. 90 91 . CC-BY-ND 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/359547 doi: bioRxiv preprint 8 pteronyssinus) protein extract (XPB82D3A2.5 from Greer) in PBS, for ten consecutive days. Cells 142 from the lungs were analyzed 24 hours post the last treatment. 143 144 Farmer's lung disease (hypersensitivity pneumonitis) model. 145