Author: Martinez-Martin, Nadia
Title: Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions Document date: 2017_2_22
ID: 1giy1fow_37
Snippet: In turn, the RNAi technology has yielded significant insights into virus-host interactions, such as the identification of the ion transporter NRAMP as the receptor for the mosquito-borne Sindbis virus colonization of Drosophila cells [41] . The main power of the RNAi technology is that it allows high throughput genome-wide screens and therefore potential identification of essential factors that play roles in different aspects of the pathogen life.....
Document: In turn, the RNAi technology has yielded significant insights into virus-host interactions, such as the identification of the ion transporter NRAMP as the receptor for the mosquito-borne Sindbis virus colonization of Drosophila cells [41] . The main power of the RNAi technology is that it allows high throughput genome-wide screens and therefore potential identification of essential factors that play roles in different aspects of the pathogen life cycle, including initial interaction with the host cell. Although RNAi screens have provided tremendous insights into host-pathogen interactions and remain widely utilized [121] , inefficient gene depletion and off-target effects are important limitations of this methodology [122] .
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